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The median age at diagnosis of AILD was 5 years for the SH2B3 single nucleotide polymorphism (SNP) group and 8 years for the non- SH2B3 SNP group, and there was no significant difference (P=0.2692 ), but the SNP group tended to develop at a slightly younger age

While there is still a lot that researchers dont know here, it looks like the SOD1 mutations cause a gain-of-function and altered folding in a way that causes a loss of motor neuron function.[ref] SOD1 Genotype Report: SOD1 genetic variants can cause either an increase or a decrease in enzyme activity

injection of 80 mg kg 1 tamoxifen in 810-week-old A(Het)KP mice (Villin-CreER T2