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Other IL cytokines and their receptors have been studied as the potential target: IL-17 inhibitor (Secukinumab) was finished in a phase III study displaying improvement in patients with active RA who had an inadequate response to TNF inhibitors

Pyroptosis is an immunogenic programmed cell death that effectively activates tumor immunogenicity and reprograms the immunosuppressive microenvironment to improve cancer immunotherapy

There's no published research showing any sort of negative interactions between the two

While this is mechanistic and cellular rather than a human weight loss trial, it provides the biological plausibility for why correcting deficiency in real people produces improvements in how energized and metabolically active they feel