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It promotes the formation of blood vessels via a process known as angiogenesis, and upregulates vascular endothelial growth factor (VEGF), a protein that stimulates blood vessel growth

In both the model and blank hydrogel groups, marked epidermal and dermal thickening was observed, accompanied by hyperkeratosis and parakeratosis in the epidermis, as well as inflammatory cell infiltration in the dermis

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Similarly, NF-B is aberrantly activated in CIN, but NF-B expression is decreased and renal tissue hyalinization, hemorrhagic casts, and necrosis are reduced after infliximab treatment (Saritemur et al., 2015)