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Reported prevalence varies across populations and study designs, with estimates ranging from approximately one-third to over one-half of respondents admitting to the use of performance-enhancing substances, including anabolicandrogenic steroids ( Available data on the non-medical use of testosterone remain limited and heterogeneous across different regions worldwide

A 2022 scientific review published in the National Library of Medicine confirmed that nasal delivery of therapeutic peptides is a non-invasive and fast-acting method that can effectively bypass the blood-brain barrier while minimising systemic exposure

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Small NADs, such as siRNA, and large ones, such as mRNA, in addition to the necessary modifications, still require the aid of delivery vectors