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Tacrolimus-Loaded Solid Lipid Nanoparticle Gel: Formulation Development and In Vitro Assessment for Topical Applications

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Periodontitis-associated salivary microbiota exacerbates colitis and anxiety in mice via gut dysbiosis and found altered metabolism of histidine in the gut and brain ( P.g could translocate to the gastrointestinal tract in a viable state and elicit insulin resistance, while administration of pasteurized P.g had no such effect ( Klebsiella aeromobilis developed colitis by inducing the accumulation of intestinal T helper 1 cells, while the inflammatory state in IBD may render the intestine more permissive to aerotolerant oral-derived bacteria than the steady-state intestine ( in vivo pathogenicity threshold of translocated oral bacteria in humans, and the mechanistic interplay between oral pathobiont virulence upregulation and gut mucosal invasion