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Under hypoxic conditions, lactate could enter fibrogenic mesenchymal progenitor cells through the GPR81 receptor to enhance their self-renewal, intensified by HIF-1 augmenting GPR81 expression [180]

doi: 10.1148/106.3.635 183 YangMWuXHuJWangYWangYZhangLet al

Lippincott, Philadelphia Choi I-Y, Lee S, Denney DR, Lynch SG (2011) Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by 1H magnetic resonance chemical shift imaging at 3 T