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1,7-9 There is general agreement, however, that abnormal processing of pain signals in the brain (central sensitization) and heightened sensitivity along peripheral pain pathways are key mechanisms underlying fibromyalgia

doi: 10.1097/01.hjh.0000220405.38622.23 53 GryglewskiRJUraczWChopickiSMarcinkiewiczE

For example, increased oxidative damage to guanine in Parkinsons disease or to specific proteins in Alzheimers disease suggests a high degree of specificity (Halliwell, 2006