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Endocrine (2019) 65:56979

These enzymes are widely involved in the regulation of many important biological processes including energy metabolism, oxidative stress, inflammation, apoptosis and aging by regulating the acetylation modification state of substrate proteins (Wu et al., 2022)

In a recent phase 3 study, the cyclophosphamide-free adjuvant chemotherapy (epirubicin and paclitaxel followed by weekly paclitaxel) was associated with a higher probability of menses resumption, compared to the cyclophosphamide-containing regimen (epirubicin and paclitaxel followed by weekly paclitaxel)