There were 28 LRD (0.6%) over a mean 23.1 years follow-up
Lordan R, Rando HM, Greene CS Dietary supplements and nutraceuticals under investigation for COVID-19 prevention and treatment

formulations in accordance with present disclosure may be administered at dosage levels sufficient to deliver a therapeutic agent dose of about 0.1 mg/kg to about 500 mg/kg body weight, from about 0.1 mg/kg to about 250 mg/kg body weight, from about 0.1 mg/kg to about 100 mg/kg body weight, from about 0.1 mg/kg to about 50 mg/kg body weight, from about 0.1 mg/kg to about 10 mg/kg body weight, and/or about 0.1 mg/kg to about 5 mg/kg body weight, from about 1 mg/kg to about 2 mg/kg body weight, from about 1mg/kg to about 10 mg/kg, from about 5mg/kg to about 15mg from about 10 mg/kg to about 20 mg/kg body weight, from about 20 mg/kg to about 30 mg/kg body weight, from about 30 mg/kg to about 40 mg/kg body weight, from about 40 mg/kg to about 50 mg/kg body weight, from about 50 mg/kg to about 60 mg/kg body weight, from about 60 mg/kg to about 70 mg therapeutic agents described herein may be any therapeutic agents described herein

However, some people will feel changes in what they experience and remember from their dreams when they take melatonin, thanks to better sleep quality and more REM sleep