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Description

Procollagen trafficking, processing and fibrillogenesis

Nat Rev Neurosci 16(6):347357

Specific deletion of Gpx4 in Tregs impairs their survival in tumors, increases infiltration of T cells into tumors, and enhances antitumor immune responses, indicating that Gpx4 maintains the survival and immunosuppressive functions of Tregs to promote tumor immune evasion [92]