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VSMC proliferation and intimal thickening also predispose individuals to oscillatory or low blood flow, which have been shown to induce leukocyte adhesion, enhanced vascular permeability, LDL oxidation, and atherosclerotic plaque formation 42,43,44

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Together, these findings support a mechanistic dissociation in which early adversity preferentially perturbs PFC bioenergetic regulation, with comparatively weaker or distinct effects in the NAc

Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment