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A general mechanistic framework is presented, in which cigarette smoke carcinogens and their metabolically activated forms cause mutations in critical growth control genes, along with other effects

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Tobacco Use and Cardiovascular Disease Infographic Details World No Tobacco Day Tobacco Use and Cardiovascular Disease Over 7 Million people die from tobacco use each year worldwide, including 890,000 from exposure to secondhand smoke Tobacco smoking and breathing in secondhand smoke can cause cardiovascular disease including: Heart Disease Stroke Tobacco use is a major cause of cardiovascular disease Tobacco use is responsible for 10% of all cardiovascular disease deaths worldwide Implementation of the World Health Organization MPOWER demand reducing measures can reduce tobacco use and help protect people from secondhand smoke