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10.1039/d4ma01215a 16 BondetV.Brand-WilliamsW.BersetC

Recent studies showed that SAS significantly increased ATF4 expression in glioma cells and induced ER stress, decreasing cell viability (145)

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Since increased -tubulin acetylation has been reported to interact with S and stabilises microtubules (Jensen et al., 2000), it could be possible that increased acetylated -tubulin stimulates S aggregations through its affinity to microtubules (Outeiro et al., 2007) and promotes cell death