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23 , e54520 (2022)

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Statistical analysis and graphical design Unless otherwise noted, statistical analyses for significant differences between groups were conducted using unpaired two-tailed t -tests without correction for multiple comparisons and without assuming consistent s.d

In obesity, the spontaneous (197, 198) and stimulated (199) pulsatile patterns of GH secretion governed by the hypothalamus are blunted, and the accumulation of abdominal adiposity, particularly visceral adipose tissue mass, was found to be a stronger negative determinant of GH secretion than other factors including age, sex, or generalized obesity (200202)