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Clinical evidence has established that elevated levels of the lipid peroxidation product 4-HNE in bronchoalveolar lavage fluid are significantly associated with poorer lung function in patients with neutrophilic asthma, underscoring its relevance as a biomarker for disease severity and potential treatment response (158)

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This dual hypertrophic-and-hyperplastic mechanism is frequently cited as what distinguishes IGF-1 LR3 from single-pathway anabolic compounds in comparative research

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