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By comparing the proteomes of control and CBS-treated HK-2 cells, we found alterations mainly toward the major metabolic pathways, including the metabolism of GSH

Regulatory sequences for mammalian host cell expression include viral elements that direct high levels of protein expression in mammalian cells, such as promoters and/or enhancers derived from cytomegalovirus (CMV), Simian Virus 40 (SV40), adenovirus (e.g., the adenovirus major late promoter (AdMLP)), and polyoma

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In parallel, metal-based agents derived from ruthenium, iron, and platinum continue to advance through experimental clinical evaluation for cancer, and ferroquine (5) has reached clinical testing for malaria (Figure 4) (Nriagu and Skaar, 2015)