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PAL exhibits strong inducibility under stress conditions, enhancing the synthesis of all phenolic compounds, including phytoalexins, thereby serving as a primary adaptive response to a number of biotic and abiotic stressors [177]

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Studies have shown that ONOO can impair mitochondrial-ATP synthesis through inhibition of mitochondrial respiratory complexes, mitochondrial polarization, and detoxifying enzymes in addition to promoting mitophagy 65,66

For lower extremity arteriosclerosis obliterans, drug-coated devices locally release anti-proliferative agents, significantly improving revascularization outcomes in femoropopliteal artery lesions ( 4.9 Modern research on traditional Chinese medicine Traditional Chinese medicine (TCM) compounds, such as Qingmai Yin and Simiao Yongan Tang, demonstrate significant efficacy in improving arteriosclerosis obliterans in clinical practice, highlighting TCMs holistic multi-component, multi-target regulatory advantages