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While its indirect effects are highly pronounced in the arterial system, its direct vasoconstrictive action operates predominantly on the venous system, making it highly effective at elevating venous return and central venous pressure (Statler et al, 2023)

Notably, it has been found that silencing long noncoding RNAs (lncRNAs) nuclear paraspeckle assembly transcript 1 (NEAT1) promotes microRNA-129 and microRNA-204 inhibition of the MAPK/ERK signaling pathway and attenuates FLS synovitis in RA ( In addition to this, it is also important to alleviate the development of RA by down-regulating various cytokines

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