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At the molecular level, both alterations in lipid metabolism and disturbances in glucose metabolism meet in the citrate cycle running inside the mitochondria and thus adversely affect their function

TABLE 7 In vivo -Studies using ICR mice

Electronic supplementary material Supplementary info Rights and permissions This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License

CHAC1 degradation of glutathione enhances cystine-starvation induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2-ATF4 pathway