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Nrf2 is the principal transcription factor in charge of protecting cells from oxidative stress through the regulation of cytoprotective genes, including the antioxidant GSH pathway, that controls GSH homeostasis by affecting de novo synthesis

18,19 EM of skin in patients with cEDS often shows characteristic florid abnormally shaped collagen fibrils known as collagen flowers although this is not specific to cEDS only

One GxE interaction hit illustrates that the fitness defect in the mitochondrial folate carrier (SLC25A32) KO cells is genetically buffered in galactose due to a lack of substrate in de novo purine biosynthesis

doi: 10.3390/metabo12040352 99 MikiYTaketomiYKidoguchiYYamamotoKMuramatsuKNishitoYet al