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Curr Colorectal Cancer Rep (2017) 13(6):45569

rodents possess a high density of GLP-1 receptors in their thyroid C-cells, which leads to hyperplasia and tumors when stimulated

Notably, controlled fluid flow introduces sustained perfusion and physiologically relevant shear forces, both of which modulate cellular behaviour and allow for a more accurate assessment of nanoparticle transport, distribution and cellular uptake than static in vitro models [175, 176]