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This methylation reaction serves important regulatory functions but also depletes NAD+ by converting it to compounds that cannot participate in NAD+-dependent metabolism

51 KalwaM.HanzelmannS.OttoS.KuoC

These factors include metabolic defects, hypoxia caused by hemoglobin glycation, changes in red blood cell membrane permeability (Brem and Tomic-Canic, 2007), and narrowing of blood vessels