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Secondly, C/J-LipoRGD liposomal nanodrugs co-deliver catalase to breakdown tumor HO and mitigate hypoxia, in conjunction with the BRD4 inhibitor JQ1 to downregulate PD-L1 expression and disrupt DNA damage repair, hence reversing T-cell fatigue and enhancing radiosensitivity [81]

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doi: 10.1016/j.bbrc.2011.03.048 166 TedescoS.ScattoliniV.AlbieroM.BortolozziM.AvogaroA.CignarellaA.et al