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doi: 10.1039/C7CP00804J 109 LiNJiangWWangWXiongRWuXGengQ

Regulatory Pathways Differ Between Liquid and Solid Submissions Drug regulatory authorities require different stability data sets depending on storage recommendations, with liquid formulations requiring additional freeze-thaw studies and accelerated-temperature stability protocols compared to ambient-stable solid formulations

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Regulatory factors like heme oxygenase 1 (HO-1) and Poly(rC) binding proteins (PCBPs) also influence iron homeostasis, with HO-1 overexpression reducing ROS and lipid peroxidation to inhibit ferroptosis, as shown by Villalpando-Rodriguez et al