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Surgical interventions, including microvascular decompression and percutaneous neuroablative procedures, can be considered at an early stage if pharmacotherapy is not sufficient for pain control or has intolerable adverse effects or contraindications

This method, typically subcutaneous or intramuscular, often represents the gold standard for achieving high and predictable bioavailability for many peptides and small molecules

Doctors must consider the pros and cons of each option and work with patients to find the best plan