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Data from DNA dot-blots and mRNA levels of Dnmt and Tet support the activity data (Fig

Orally administered aripiprazole produced retinal degeneration in albino rats in a 26-week chronic toxicity study at a dose of 60 mg/kg, which is 19 times the oral MRHD of 30 mg/day on mg/m basis, and in a 2-year carcinogenicity study at doses of 40 mg/kg and 60 mg/kg, which are 13 and 19 times the oral MRHD on mg/m basis and 7 to 14 times human exposure at the oral MRHD based on AUC

Kim S, Keku TO, Martin C, Galanko J, Woosley JT, Schroeder JC, et al

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