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Evidence from animal models demonstrates that reactivating mitophagy effectively limits the inflammatory microenvironment, reduces angiogenesis, and promotes the clearance of ectopic cells

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described as a pattern of injury similar to ischemic hepatitis

Chronically administered opioids are known (1) to alter cellular redox status, thus inducing an oxidative state, and (2) for an overall decrease in DNA methylation, therefore resulting in the transcriptional activation of previously silenced long interspersed elements (LINE-1) retrotransposon genes