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Current NHS and NICE guidance emphasises lifestyle modificationincluding weight loss, dietary improvement, and increased physical activityas the cornerstone of management, with antioxidant supplementation playing at most a limited, specialist-supervised role in carefully selected patients

Curr Biol CB (2014) 24(19):227480

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Neutral Side Chains For amino acids containing neutral side chains, they possess two pKa values corresponding to the carboxyl group (pKa1) and the amino group (pKa2)