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Mechanistic pathways of selenium in the treatment of Graves disease and Graves orbitopathy

Although the exact physiological role remains under study, DSIP has been associated with modulation of hypothalamic and pituitary activity in experimental models

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Chromatography was performed on a Kinetex 2.6 m HILIC 100 , 100 2.1 mm internal diameter column (Phenomenex), with a constant flow rate of 250 l/min and a solvent gradient from 20% Mobile Phase B (50:45:5, ACN:H 2 O:100 mM AmFm in H 2 O) to 22% B at 5 min, 40% B at 10 min, 60% B at 13 min, 80% B at 15 min, and 99% B at 20 min