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The 2016 revised statement on e-cigarettes by the US Flavoring and Extract Manufacturers Association about these chemicals (which have been safety assessed for use in foods and beverages, but not for inhalation) is further cause for concern: The manufacturers and marketers of e-cigarettes and all other flavored tobacco products, and flavor manufacturers and marketers, should not represent or suggest that the flavor ingredients used in these products are safe because they have FEMA GRASTM status for use in food because such statements are false and misleading

Instead, the cells with damaged DNA go on to divide uncontrollably, leading to the development of tumors (bottom row)

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Infection by SARS-CoV-2 of olfactory epithelium already in an inflammation state may facilitate the virus infection efficiency as its receptor ACE2 is overexpressed during inflammation (Ziegler et al., 2020)