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Description

The microchannels increase skin permeation more than twentyfold compared with intact skin

Challenges and opportunities in nanotherapeutics targeted for central nervous system disorders

The nervous system is widely involved in the initiation, invasion, extravasation, colonization, and immune evasion of tumor cells by releasing neurotransmitters and neuropeptides [251, 252]

Particularly relevant in the brain, arginase serves as a substrate for nitric oxide synthase, which produces nitric oxidean important cellular messenger (Wiesinger, 2001)