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4G, with significant pathways including Arachidonic acid metabolism (P = 0.0009), Biosynthesis of unsaturated fatty acids (P = 0.0010), Linoleic acid metabolism (P = 0.0335), and Ferroptosis (P = 0.0398)

Hydrogen-producing bacteria are associated with diarrhoea, while methane-producing microorganisms (now classified as intestinal methanogen overgrowth or IMO) are more closely linked to constipation

The ILD component of CTD is a major determinant of morbidity and mortality in CTDs and new developments from clinical trials have started yielding results to fill the urgent need for new therapies for CTD-ILD

Smart et al.s work in Nature on Thymosin Beta-4s role in endogenous cardiac progenitor cell activation following injury illustrates the breadth of Thymosin Beta-4s tissue remodeling activity [2]