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While efficacy matters, the tolerability and adverse effect profile often determines whether a treatment is suitable for long-term use

3 It has been debated for many years whether oral glutathione supplementation translates into increased bioactive levels of glutathione in the body, since many believe that oral glutathione cannot be adequately absorbed and therefore, successfully utilized by the bodys cells

In addition, the lack of B12 also results in reduced production of melatonin, contributing to poor gut health - often seen in CFS and also to poor sleep patterns, also characteristic of CFS