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This situation can disrupt the load balance on the patients hips and knees or lead to bowed legs, also known as X leg deformity

Supraphysiologic amounts of labile iron can promote ferroptosis through facilitation of the Fenton reaction or activation of iron-dependent enzymes (Stockwell 2022)

Radionuclide-linked nanotherapeutics connect imaging, dosimetry and localized radiation delivery, with translational issues related to radiolabel stability, normal-tissue dose, long-term retention and sequencing with systemic therapies [72, 74, 85, 89]