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It has been reported that the variation in clinical effectiveness of triple combination cream and hydroquinone was more obvious in patients with darker skin tones and also in those with mixed type of melasma ( 5.1.6 Azelaic acid Azelaic acid can inhibit the mitochondrial enzyme and DNA synthesis in melanocytes, which might be cytotoxic

These findings underscore the importance of context, dosage regimen, and metabolic environment, reinforcing that the systemic benefits of lactate may be counteracted by localized biochemical disturbances in muscle tissue

We found that GPX4 immunoreactivity is actually increased relative to the cell density of surviving SN neurons (Figure 4C)

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