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ADO leads to tumor growth and skews the immune cells toward an immunosuppressive phenotype ( Figure 2 Adenosinergic pathways identified on different cell populations ( ADO is produced from the catabolism of mono- and di-nucleotides of adenine (ATP, NAD + and cAMP) (Figure 1)

This makes the overall treatment with semaglutide more comfortable and tolerable, ensuring better adherence and more consistent results for patients

Species Several ASVs mapped with high confidence directly to a specific species (Supplementary Table S4), with considerably more species mapped using the BLASTn method compared to the BLCA method

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