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The Recommended COVID-19 Vaccine Schedules in a nutshell. For immunocompromised patients (immunodeficiency disorders and people on immunosuppressants): Pfizer patients: Shot #2 = 3-8 weeks after shot #1 Shot #3 = 4 weeks after shot #2 Shot #4 = (booster) 3 months after shot #3 Shot #5 = (booster) 4 months after shot #4 Moderna patients: Shot #2 = 4-8 weeks after shot #1 Shot #3 = 4 weeks after shot #2 Shot #4 = (booster) 3 months after shot #3 Shot #5 = (booster) 4 months after shot #4 J&J patients: Shot #2 = (Pfizer or Moderna) 4 weeks after shot #1 Shot #3 = (Pfizer or Moderna) 2 months after shot #2 Shot #4 = (booster) 4 months after shot #3 What is a Mix-and-Match COVID-19 Booster Shot? The CDC has approved something called mix-and-match, where someone can get a COVID vaccine that is different than their initial primary series