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Therefore, it is possible that the mechanism of RGMa-dependent inhibition of hippocampal neurogenesis partially underlies the therapeutic effect of Metformin and SGLT2 inhibitors on diabetes-related cognitive impairment

Clinical signs are indistinct and include lethargy, depression, ataxia, anorexia and intermittent vomiting, and in severe cases, can induce neurological disease and blindness in cats