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Parental Psychopathology: Caregivers with mental health issues, such as depression, anxiety, or substance abuse disorders, may struggle to provide the necessary emotional support and stability, contributing to the development of DSED in their children

Furthermore, NF-B modulates p53-mediated apoptosis via promoting the polyubiquitylation and degradation of p53

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Cell Death Differ 9:367393 La SR, Ndhlovu A, Durand PM (2022) The ancient origins of death domains support the original sin hypothesis for the evolution of programmed cell death