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The result is increased NAD+ levels, but through conservation rather than supplementation

The induction of diabetes and CKD using STZ and adenine, respectively, in the experimental animals resulted in significant hyperglycemia, weight loss, polyuria, impaired renal function and structure, and increased oxidative stress accompanied by a compromised antioxidant defense system and dysregulated inflammatory markers

Protein Methylation in Mitochondria Journal of Biological Chemistry (2022) 298, Article ID: 101791

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