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In addition, section 1833(t)(2) of the Act provides that, subject to certain exceptions, the items and services within an APC group cannot be considered comparable regarding the use of resources if the highest cost for an item or service in the group is more than 2 times greater than the lowest cost for an item or service within the same group (referred to as the 2 times rule)

Topical treatments may take several weeks to months to show improvement, while medical procedures like laser therapy or fillers can offer more immediate results

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