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Int J Pharm Qual Assur 15(3):11681170

Neuroreport 22, 721726

A schematic illustration depicting GSH synthesis, its oxidation to GSSG, and the subsequent reduction of GSSG back to GSH using NADPH is shown in Fig

Mechanistically, the inflammatory human caspase-1/4/5 and mouse caspase-1/11 as well as caspase-3, serine protease, mediate proteolytic cleavage of corresponding gasdermins (GSDMs) and liberate N-terminal (NT) fragments binding to phospholipids in inner plasma membrane to form pores, enabling the release of pro-inflammatory cytokines and plasma membrane rupture 5,6,7,8