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GHK-Cu is sensitive to pH, light, oxygen and heat

This approach revealed key interactions between the receptor's transmembrane and extracellular domains, suggesting that K1-70 inhibits TSHR by binding without activating it, while the stimulatory autoantibody M22 likely induces activation through conformational changes in the hinge region (254)

It is possible that interactions could occur with certain medications, including insulin, blood thinners, and chemotherapy

In intact skin without a penetration enhancer (such as ethosomes, liposomes, or hyaluronic acid conjugation), multiple ex vivo tape-stripping studies show that most topically applied GHK-Cu accumulates in the stratum corneum and upper viable epidermis, not in the dermis where fibroblasts live