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Experiments performed in differentiated SH-SY5Y neuroblastoma cells have shown that exposure to PS-NPs downregulates expression of the CI subunit NDUFB8, leading to diminished basal and maximal oxygen consumption rates alongside increased proton leakagefurther confirming mitochondrial CI dysfunction 32

[5] By simultaneously providing all these B vitamins, the injection ensures that the body has all necessary co-factors in adequate supply

van de Loosdrecht AA, Beelen RH, Ossenkoppele GJ, Broekhoven MG, Langenhuijsen MM (1994) A tetrazolium-based colorimetric MTT assay to quantitate human monocyte mediated cytotoxicity against leukemic cells from cell lines and patients with acute myeloid leukemia

Rosen H, Klebanoff SJ (1979) Bactericidal activity of a superoxide anion-generating system