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Vitamin absorption after gastric bypass surgery is heavily reliant on the patient complying with prescribed supplements, and physicians diligently monitoring patients for micronutrient deficiencies

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Early evidence already suggests that such multiplex regimens outperform single-agent therapy where metabolic heterogeneity blunts isolated responses (81, 85) (Table 3) Future work must dissect mechanism-specific dosing ratios, develop quantitative biomarkers of combinatorial efficacy, and deliver large, stratified, randomized trials to confirm both safety and clinical relevance

Ahmed HU, El-Shater Bosaily A, Brown LC, Gabe R, Kaplan R, Parmar MK, et al