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The structural change ( Figure 7E ) could potentially hinder the transamination reaction, because the loop movement might bring the -amino group of PMP into closer proximity to other amino-acid side groups, such as His192, promoting the hydrogen bond formation that may influence the reactivity of PMP with GSA

J Appl Physiol 106:98895

SLC38A2 is a Na+ ion-dependent neutral amino acid transporter belonging to the SLC38 family of transporters that drives glutamine flow into cells [45]