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Description

Necrostatin-1 reduces intestinal inflammation and colitis-associated tumorigenesis in mice

The complex formed by PIWI-interacting RNA-36741 (piR-36741) and PIWIL4 reduces the methylation activity of METTL3, obstructing the m 6 A modification of BMP2 mRNA, preventing the degradation of BMP2 mRNA mediated by YTHDF2 and enhancing BMP2 expression to accelerate BMSC osteogenic differentiation [85]