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In a 2001 study published in Endocrinology , Heffernan and colleagues reported that chronic AOD-9604 administration reduced body weight gain, decreased adipose tissue mass, and increased fat oxidation in obese mice without altering IGF-1 levels or glucose metabolism effects that were abolished in beta3 adrenergic receptor (3-AR) knockout mice, implicating 3-AR signaling as the mechanism of action [1]

BMJ Journals

Flavonoids vary enormously in their chemical structures, but the basic framework is made up of 15 carbon atoms (C6-C3-C6) that form two aromatic rings (A and B) linked by a 3-carbon chain which leads to an oxygenated heterocycle (C).[21] (Figure 1)

Another study that included 256 children showed that those with a deficiency of vitamin B12 had a higher than average body mass index