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Shelef A, Barak Y, Berger U, Paleacu D, Tadger S, Plopsky I, et al

The cells were cultured in DMEM with 10% fetal bovine serum and 1% (v/v) penicillin/streptomycin

Their findings indicated that cynaroside upregulated uncoupling protein 1 (UCP-1), PPAR-, CYP7A1 and carnitine palmitoyltransferase I (CPT-1) protein expression, and downregulated C/EBP, PPAR and fatty-acid synthase (FASN) proteins to regulate lipid metabolism