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The overall prevalence of NASH is uncertain, as it relies on third-level referral centers with availability of liver biopsies, and is estimated between 1.5 and 6.45% (34)

Moreover, abnormality of the vessel wall is likely to result from increased synthesis of extracellular matrix (ECM) by intimal and adventitial fibroblasts

[9] [29] Guidelines from the American Association for the Study of Liver Diseases and the American College of Gastroenterology do not support the use of UDCA but guidelines from the European Association for the Study of the Liver do endorse the use of moderate doses (1315 milligrams per kilogram) of UDCA for PSC

56 The presence of glomerulations on endoscopy is too non-specific to make the diagnosis of IC/BPS